Table 4. Responses of icotinib therapy in patients according to total EGFR expression and EGFR FISH^a.

Tumor status	No. of evaluated Patients	Complete responses and partial responses		P value	Stable disease
		No.	%		No.	%
Total	62	9	14.5		20	32.3
EGFR expression
1+, or 2+	11	0	0	0.341b	3	27.3
3+	51	9	17.6		17	33.3
EGFR FISHc
Negative	39	4	10.3	0.713b	14	35.9
Positive	22	4	18.2		6	27.3
Unknown	1	1	100		0	0

^aFluorescence In Situ Hybridization

^bTested by Fisher's exact test

^cone case was exclude because the result of EGFR FISH couldn't be detected