Table 1. Association between hypermethylation frequency and risks of gastric cancer and atrophic gastritis.
| GC vs CON | GC vs AG | AG vs CON | GC vs AG + CON | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GC | AG | CON | Pa | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | ||
| M3 | Lb | 101 (63.5) | 76 (40.9) | 160 (95.2) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | ||||
| Hc | 58 (36.3) | 110 (59.1) | 8 (4.8) | < 0.001 | 11.43 (4.95, 26.41) | < 0.001 | 0.36 (0.22, 0.59) | < 0.001 | 25.05 (10.51, 59.71) | 0.981 | 0.98 (0.64, 1.51) | |
| M5 | L | 120 (75.5) | 171 (92.4) | 163 (97.0) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | ||||
| H | 39 (24.5) | 14 (7.6) | 5 (3.0) | < 0.001 | 10.28 (3.70, 28.56) | < 0.001 | 3.86 (1.94, 7.68) | 0.083 | 2.91 (0.87, 9.70) | < 0.001 | 5.85 (3.20, 10.69) | |
| M7 | L | 117 (73.6) | 77 (41.6) | 160 (95.2) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | ||||
| H | 42 (26.4) | 108 (58.4) | 8 (4.8) | < 0.001 | 7.26 (3.12, 16.89) | < 0.001 | 0.23 (0.14, 0.37) | < 0.001 | 22.70 (9.93, 51.95) | 0.028 | 0.60 (0.38, 0.95) | |
| M8 | L | 122 (76.7) | 127 (68.6) | 160 (95.2) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | ||||
| H | 37 (23.3) | 58 (31.4) | 8 (4.8) | < 0.001 | 6.43 (2.74, 15.27) | 0.065 | 0.61 (0.37, 1.03) | < 0.001 | 9.28 (3.95, 21.84) | 0.406 | 1.23 (0.76, 1.98) | |
| M20 | L | 111 (69.8) | 108 (58.4) | 158 (94.0) | 1 (Ref., | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | ||||
| H | 48 (30.2) | 77 (41.6) | 10 (6.0) | < 0.001 | 5.22 (2.42, 11.27) | 0.012 | 0.54 (0.33, 0.87) | < 0.001 | 7.78 (3.60, 16.82) | 0.608 | 1.13 (0.72, 1.76) | |
| M25 | L | 78 (49.1) | 53 (28.6) | 145 (86.3) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | ||||
| H | 81 (50.9) | 132 (71.4) | 23 (13.7) | < 0.001 | 5.82 (3.24, 10.47) | < 0.001 | 0.411 (0.26, 0.66) | < 0.001 | 10.77 (5.88, 19.71) | 0.326 | 1.23 (0.82, 1.84) | |
| M27 | L | 113 (71.1) | 165 (89.2) | 157 (93.5) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | ||||
| H | 46 (28.9) | 20 (10.8) | 11 (6.5) | < 0.001 | 5.29 (2.44, 11.44) | < 0.001 | 3.16 (1.72, 5.80) | 0.067 | 2.31 (0.94, 5.64) | < 0.001 | 4.27 (2.54, 7.19) | |
| M30 | L | 82 (51.6) | 48 (25.9) | 150 (89.3) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | ||||
| H | 77 (48.4) | 137 (74.1) | 18 (10.7) | < 0.001 | 7.13 (3.81, 13.36) | < 0.001 | 0.31 (0.19, 0.51) | < 0.001 | 15.28 (8.07, 28.93) | 0.68 | 1.09 (0.73, 1.64) | |
a
P value and odd ratio(OR) were adjusted by sex, age, smoking, drinking and H.pylori infection. P value OR and corresponding 95% interval confidence were calculated to measure the association between hypermethylation of CpG site and the risks of different groups
b
the number of hypomethylated cases
c
H:hypermethylation. GC: gastric cancer; AG: atrophic gastritis; CON: control; OR: odd ratio; CI: interval confidence.