Table 3. Relationship between H.pylori infection and DNA methylation of RNF180 promoter area in different gastric diseases.
| Group | H.pylori | n | Average Methylation Rate |
Methylated CpG sites count | Hypermethylated CpG sites count | |||
|---|---|---|---|---|---|---|---|---|
| Median (25th, 75th) | P | Median (25th, 75th) | P | Median (25th, 75th) | P | |||
| GC | (−) | 84 | 0.28 (0.15, 0.36) | 0.761 | 14 (3.5, 23.75) | 0.744 | 5 (0, 8) | 0.697 |
| (+) | 75 | 0.26 (0.17, 0.34) | 14 (4, 21) | 4 (0, 7) | ||||
| AG | (−) | 55 | 0.23 (0.09, 0.31) | 0.581 | 9 (1, 16) | 0.494 | 4 (0, 6) | 0.634 |
| (+) | 131 | 0.24 (0.21, 0.29) | 10 (7, 14) | 4 (3, 5) | ||||
| CON | (−) | 143 | 0.05 (0.03, 0.12) | 0.012 | 0 (0, 1) | 0.108 | 0 (0, 0) | 0.037 |
| (+) | 25 | 0.08 (0.51, 0.32) | 0 (0, 19) | 0 (0, 3) |
P value for Mann-Whitney U test comparing the difference of variables between H.pylori positive and negative groups. GC: gastric cancer; AG: atrophic gastritis; CON:control.