Fig 7. Reduced Akt and GSK3β phosphorylation in the renal cortex of db/db mice is restored by atorvastatin.

Phosphorylation levels of Akt (A) and GSK3β (B) were evaluated in renal cortex isolated from db/+ and db/db mice treated with atorvastatin (10 mg/kg/day for 2 weeks) or control diet. Top panels, representative immunoblots of Akt [Ser⁴⁷³], GSK3β [Ser⁹] and β-actin. Results are mean ± SEM of 6–8 mice in each experimental group. *P< 0.05 vs. db/+ control diet, **P<0.05 db/db atorvastatin diet vs. db/db control diet.