Table 2. Clinical and biochemical characteristics and allelic frequency of the patients with adrenal incidentalomas categorized for cortisol secretion after the 1 mg DST.
| Group 1 | Group 2 | Group 3 | ||
|---|---|---|---|---|
| N = 229 | N = 92 | N = 90 | ||
| Age (years) | 59.7 ± 10.1 | 65.1 ± 8.6 | 63.2 ± 9.5 | 1 vs 2, p<0.001; 1 vs 3, p = 0.005; 2 vs 3, p = 0.15 |
| Sex (% women) | 64.9 | 60.3 | 66.7 | 1 vs 2, p = 0.4; 1 vs 3, p = 0.7; 2 vs 3, p = 0.4 |
| BMI >25 Kg/m2 (%) | 79.1 | 73.2 | 72.7 | 1 vs 2, p = 0.2; 1 vs 3, p = 0.2; 2 vs 3, p = 0.9 |
| Elevated waist (%) | 55.5 | 50.0 | 51.3 | 1 vs 2, p = 0.4; 1 vs 3, p = 0.5; 2 vs 3, p = 0.9 |
| Hypertension (%) | 59.7 | 69.0 | 72.8 | 1 vs 2, p = 0.1; 1 vs 3, p = 0.03; 2 vs 3, p = 0.6 |
| Diabetes (%) | 24.0 | 28.4 | 36.6 | 1 vs 2, p = 0.4; 1 vs 3, p = 0.02; 2 vs 3, p = 0.2 |
| Dyslipidemia (%) | 41.6 | 48.8 | 46.8 | 1 vs 2, p = 0.2; 1 vs 3, p = 0.8; 2 vs 3, p = 0.4 |
| UFC (% ULN) | 8.7 | 16.5 | 15.3 | 1 vs 2, p = 0.04; 1 vs 3, p = 0.08; 2 vs 3, p = 0.8 |
| ACTH (pg/ml) | 17.9 ± 16.4 | 12.9 ± 8.8 | 9.2 ± 6.8 | 1 vs 2, p = 0.006; 1 vs 3, p<0.001; 2 vs 3, p = 0.001 |
| N363S % (n) (MAF) | 4.8% (11) 0.023 | 5.4%(5) 0.034 | 6.6% (6) 0.028 | 1 vs 2 p = 0.6, 1 vs 3 p = 0.8, 2 vs 3 p = 0.8 |
| BclI % (n) (MAF) | 53.2% (122) 0.321 | 56.5% (52) 0.346 | 53.3% (48) 0.322 | 1 vs 2 p = 0.5, 1 vs 3 p = 0.9, 2 vs 3 p = 0.7 |
| ER22/23EK % (n) (MAF) | 5.2% (12) 0.026 | 3.2% (3) 0.021 | 3.3% (3) 0.017 | 1 vs 2 p = 0.8, 1 vs 3 p = 0.6, 2 vs 3 p = 0.8 |
GROUP 1 = Cortisol ≤ 1.8 mcg/dL
GROUP 2 = Cortisol >1.9 mcg/dL and ≤3 mcg/dL
GROUP 3 = Cortisol >3 mcg/dL
ULN = Upper limit of normality
Continuous variable are expressed as mean ± SD
To convert conventional units to SI units: for cortisol, multiply by 27.59 to obtain nanomoles per liter; for ACTH, multiply by 0.22 to obtain picomoles per liter.