Table 3.
Drug-loading (DL) efficiency of BSA-NPs in different AS concentrations (mean ± standard deviation; n=3)
| AS concentration (mg/mL) |
ABNI
|
ABNA
|
||
|---|---|---|---|---|
| DLa | BSA:ASb | DLa | BSA:ASb | |
| 0.5 | 1.2±0.3 | 1:2 | 1.9±0.03 | 1:4 |
| 1.0 | 2.5±0.3 | 1:4 | 1.9±0.7 | 1:4 |
| 2.0 | 4.1±0.9 | 1:8 | 2.3±1.2 | 1:4 |
Notes:
a
Loading efficiency (mg/100 mg);
b
one BSA molecule combined with various amounts of AS (mol:mol) on average.
Abbreviations: AS, albuterol sulfate; BSA, bovine serum albumin; ABNI, BSA nanoparticles carrying AS prepared by incorporation; ABNA, BSA nanoparticles carrying AS prepared by adsorption.