. 2016 Sep 20;11(9):e0163166. doi: 10.1371/journal.pone.0163166

Table 2. Nucleotide substitution rates and divergence times over 12 years for the VP1 gene of GII.4 NoV variants in China(n = 174, 1623 nt)^a.

Molecular clock	Nucleotide substitution rate	TMRCA by:
Molecular clock	(10⁻³ substitutions/site/year)	No. of year	Date (range)
Strict clock	4.74 (4.12, 5.41)	19.6 (17.9, 21.4)	1994.4 (1978.4, 1996.1)
UCLN	6.99 (5.54, 8.59)	13.4 (12.4, 14.3)	2000.6 (1999.7, 2001.6)
UCED	7.68 (6.14, 9.29)	13.2 (12.4, 14.1)	2000.8 (1999.9, 2001.6)

^aThe nucleotide substitution rate is the mean rate for the three individual determinations. UCLN, uncorrelated log-normal clock. UCED, uncorrelated exponential deviation clock. TMRCA, time to most recent common ancestor. Values in parentheses are 95% HPDs.

Table 2. Nucleotide substitution rates and divergence times over 12 years for the VP1 gene of GII.4 NoV variants in China(n = 174, 1623 nt)a.

Table 2. Nucleotide substitution rates and divergence times over 12 years for the VP1 gene of GII.4 NoV variants in China(n = 174, 1623 nt)^a.