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. 2016 Aug 11;38(4):1063–1074. doi: 10.3892/ijmm.2016.2706

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Copyright: © Mateu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Proliferation and migration of fibroblasts. (A) No differences were found in the proliferation of neonatal fibroblasts (NFs) and adult fibroblasts (AFs) as measured by the MTT assay. (B) The migration of both cell types from microdrops significantly differed. While NFs remained more clustered, AFs migrated further from the original drop (MTT assay before the formazan dissolution). (C) At day 7 twenty clusters of each cell type (from 3 biological replicates) were used for the statistical evaluation. A statistically significant difference between AFs and NFs was found (P<0.001). (D) Adult keratinocytes (AKs) and newborn keratinocytes (NKs) did not differ in their effect on fibroblasts. While NFs influenced by keratinocytes increased their migration potential, in the case of AFs, it remained identical. MTT assay before the formazan dissolution, detail of the space between neighboring drops. Scale bar is 100 μm.