Fig. 2.

Timeline and endpoints for the hamster study design. To demonstrate the ability of our dark field system to monitor in vivo vascular changes during carcinogenesis in an inducible cancer model, non-invasive cross-polarized dark field (CPDF) images were obtained from hamster cheek pouches at week 12, 14 and 17 after treatment with dimethylbenz[a]anthracene (DMBA). Biopsies were obtained at week 17 from the sites that were imaged to confirm the induction of cancer.