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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Transplantation. 2016 Oct;100(10):2039–2047. doi: 10.1097/TP.0000000000001319

Figure 2.

Figure 2

Figure 2

Figure 2

Histopathology of (A) hyperacute rejection (<24 hours) in a wild-type pig liver transplanted orthotopically into a baboon, (B) a GTKO/hCD46 orthotopic pig liver graft in a baboon that survived for 6 days, and (C) a pig left liver lobe graft in a Tibetan monkey that survived for 14 days

(A) WT pig-to-baboon liver xenotransplantation at 1 h (x200). Severe hepatocellular vacuolar change, focal hepatocyte necrosis, and few thrombi.

(B) Vacuolar hepatocellular cytoplasmic change with minimal hepatocellular necrosis on postoperative day 6 (x200).

(C) The graft shows some lymphocyte infiltration in the portal area, but no major features of antibody-mediated or cellular rejection (x100).