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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Transplantation. 2016 Oct;100(10):2039–2047. doi: 10.1097/TP.0000000000001319

Figure 6.

Figure 6

Potential mechanism of human platelet phagocytosis by pig livers - 2. Schematic representation of CD47-SIRPα (signal regulatory protein-alpha) interaction in relation to natural expression of SIRPα on pig Kupffer cells; (Left) In the organ-source pig, there is a normal inhibitory signal of pig CD47 (in this example expressed on platelets) that is recognized by porcine SIRPα; (Center) After pig liver xenotransplantation, there could be a lack of recognition of human CD47 by pig SIRPα, resulting in phagocytosis of human platelets; (Right) Transgenic expression of human SIRPα on pig Kupffer cells would result in recognition of human CD47 on human platelets, thus inhibiting phagocytosis. (Reproduced with permission from Ekser et al. Expert Rev. Clin. Immunol. 2012;8:621–634)