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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Hippocampus. 2016 Jun 2;26(10):1276–1290. doi: 10.1002/hipo.22604

Figure 2. Alterations in GABAergic inhibition in dentate gyrus granule cells following chronic stress.

Figure 2

a, Representative traces of sIPSCs in dentate gyrus granule cells from minimally-handled controls or mice subjected to chronic restraint stress. b, Superimposed traces of average sIPSCs normalized to the peak amplitude from control and chronic stress mice showing no change in the decay time constant. c, There is no difference in the frequency of sIPSCs between controls and mice subjected to chronic stress. The average peak amplitude of sIPSCs recorded in dentate gyrus granule cells is increased in chronic stress mice compared to controls. d-e, Representative traces of tonic currents in dentate gyrus granule cells from minimally-handled controls or mice subjected to chronic restraint stress recorded by blocking GABAARs with either SR95531 (d) or picrotoxin (e). f, Tonic inhibition measured using either SR95531 or picrotoxin is decreased in dentate gyrus granule cells in slices from mice subjected to chronic stress compared to minimally-handled controls. n = 13 – 27 cells, 7 – 11 mice per experimental group. * denotes significance of p<0.05 using a Student’s t-test.