Skip to main content
. Author manuscript; available in PMC: 2017 Oct 20.
Published in final edited form as: Mol Biosyst. 2016 Jul 25;12(10):3067–3087. doi: 10.1039/c6mb00231e

Figure 2. Examples of proteins with potentially allosteric OTH binding sites.

Figure 2

Proteins are represented in cartoon format. The monomer structure with identified binding sites is in white. SiteMap binding sites are shown as spheres, bound ligands are shown as ball-and-sticks. A, SULT2B1 (PDB: 1q1q.A) with an ENZ binding site occupied by a nucleotide and three additional OTH binding sites (green, blue, yellow). B, RET (PDB: 2iiv.A) with an ENZ binding site occupied by the bound inhibitor and an additional OTH binding site (green). C, CHP2 (PDB: 2bec.A) with two PPI binding sites (green, blue) at the interface with SL9CA1 (PDB: 2bec.B) and an additional OTH binding site (peach). D, The superimposed structure of PLAUR (PDB: 1ywh.M) with two PPI binding sites at the interfaces with VTN (PDB: 3bt1.B, green) and PLAU (PDB: 3bt1.A, yellow) and an additional OTH binding site (peach).