Table 7.
Uncommon cancer targets with druggable binding site
| Protein | Network | Signaling Pathways | Cancer | Binding site | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbol | Name | Degree | Betweenness (×106) | Disease | FC | HR (95% CI) | Publications | Structure | All | ENZ | PPI | OTH | |
| KPNA2 | Importin subunit alpha-1 | 50 | 3152.3 | BRCA LUAD |
2.2 2.0 |
1.8 (1.2 – 2.7) 1.5 (1.0 – 2.1) |
55 | 4E4VB | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| FBP1 | Fructose-1,6-bisphosphatase 1 | 16 | 820.8 | GBM | 2.6 | 1.5 (1.0 – 2.3) | 34 | 2FHYA | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| KIF23 | Kinesin-like protein KIF23 | 10 | 61.5 | LUAD | 2.9 | 1.6 (1.1 – 2.4) | 25 | 3VHXH | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| ORM1 | Alpha-1-acid glycoprotein 1 | 7 | 59.0 | KIRC | 6.1 | 1.4 (1.0 – 1.9) | 25 | 3KQ0A | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| PTPN22 | Tyrosine-protein phosphatase non-receptor type 22 | 6 | 12.7 | KIRC | 2.2 | 1.5 (1.1 – 2.1) | 23 | 4J51B | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| EPHA8 | Ephrin type-A receptor 8 | 5 | 99.1 | UCEC | 5.4 | 4.7 (1.0 – 21.5) | 14 | 3KULB | 1 | 1 | 0 | 0 | |
|
| |||||||||||||
| ERO1L | ERO1-like protein alpha | 4 | 10.7 | LUAD | 2.2 | 1.7 (1.2 – 2.4) | 13 | 3AHQA | 2 | 1 | 0 | 1 | |
|
| |||||||||||||
| PKMYT1 | Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase | 4 | 6.1 | Cell cycle | KIRC | 2.9 | 1.9 (1.4 – 2.7) | 14 | 3P1AA | 1 | 1 | 0 | 0 |
|
| |||||||||||||
| TDO2 | Tryptophan 2,3-dioxygenase | 3 | 403.6 | KIRC | 2.7 | 1.5 (1.1 – 2.1) | 52 | 4PW8F | 1 | 1 | 1 | 0 | |
|
| |||||||||||||
| GCKR | Glucokinase regulatory protein | 2 | 200.8 | KIRC | 2.9 | 2.5 (1.8 – 3.5) | 15 | 4OLHA | 3 | 0 | 0 | 3 | |
|
| |||||||||||||
| SERPINB3 | Serpin B3 | 2 | 4.6 | LUAD | 2.2 | 1.7 (1.2 – 2.4) | 35 | 2ZV6A | 3 | 0 | 0 | 3 | |
|
| |||||||||||||
| ADAMTS4 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 2 | 2.2 | KIRC | 2.0 | 1.6 (1.2 – 2.2) | 18 | 2RJPC | 1† | 1 | 0 | 0 | |
|
| |||||||||||||
| SERPINB4 | Serpin B4 | 2 | 1.7 | LUAD UCEC |
4.0 5.0 |
1.5 (1.0 – 2.1) 4.6 (1.2 – 17.1) |
7 | 2ZV6A | 3 | 0 | 0 | 3 | |
|
| |||||||||||||
| MELK | Maternal embryonic leucine zipper kinase | 1 | 0.0 | BRCA LUAD KIRC UCEC |
3.9 2.7 4.0 3.9 |
1.6 (1.0 – 2.3) 1.7 (1.2 – 2.3) 1.5 (1.0 – 2.1) 3.6 (0.9 – 3.6) |
63 | 4UMUA | 2† | 1 | 0 | 1 | |
|
| |||||||||||||
| PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | 1 | 0.0 | Calcium, Wnt, Phosphatidylinositol | KIRC | 2.2 | 1.5 (1.1 – 2.0) | 8 | 2ZKMX | 4 | 0 | 0 | 4 |
|
| |||||||||||||
| PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 1 | 0.0 | Citrate, PPAR, PI3K-Akt | LUAD | 3.8 | 1.5 (1.0 – 2.1) | 15 | 2GMVA | 1 | 0 | 0 | 1 |
|
| |||||||||||||
| TNFAIP8L2 | Tumor necrosis factor alpha-induced protein 8-like protein 2 | 1 | 0.0 | KIRC | 2.4 | 1.6 (1.1 – 2.2) | 3 | 3F4MA | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| ANXA8L2 | Annexin A8-like protein 2 | 0 | 0.0 | KIRC | 2.1 | 1.7 (1.3 – 2.4) | 0 | 1W45B | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| GSG2 | Serine/threonine-protein kinase haspin | 0 | 0.0 | BRCA | 2.0 | 1.6 (1.1 – 2.4) | 5 | 3DLZA | 1† | 1 | 1 | 0 | |
|
| |||||||||||||
| RNASET2 | Ribonuclease T2 | 0 | 0.0 | KIRC | 3.2 | 1.9 (1.3 – 2.6) | 27 | 3T0OA | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| NCF1C | Putative neutrophil cytosol factor 1C | 0 | 0.0 | GBM | 2.5 | 1.8 (1.2 – 2.7) | 0 | 1NG2A;1KQ6A | 2 | 0 | 2 | 0 | |
|
| |||||||||||||
| XDH | Xanthine dehydrogenase/oxidase | 0 | 0.0 | KIRC LUAD |
2.2 4.5 |
1.5 (1.0 – 2.1) 1.9 (1.4 – 2.7) |
34 | 2E1QD | 9 | 1 | 0 | 8 | |
|
| |||||||||||||
| CHI3L2 | Chitinase-3-like protein 2 | 0 | 0.0 | GBM KIRC |
4.8 2.5 |
1.9 (1.3 – 2.9) 2.0 (1.5 – 2.8) |
5 | 4P8XA | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| ALDH1L1 | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 0 | 0.0 | LUSC | 2.5 | 1.4 (1.0 – 1.9) | 23 | 2CFIA | 1 | 1 | 0 | 0 | |
|
| |||||||||||||
| AKR1D1 | 3-oxo-5-beta-steroid 4-dehydrogenase | 0 | 0.0 | KIRC | 4.5 | 1.6 (1.2 – 2.2) | 5 | 3UZWB | 1 | 1 | 0 | 0 | |
|
| |||||||||||||
| SERPIND1 | Heparin cofactor 2 | 0 | 0.0 | KIRC | 3.8 | 1.6 (1.2 – 2.2) | 5 | 1JMOA | 2 | 0 | 0 | 2 | |
|
| |||||||||||||
| TCN1 | Transcobalamin-1 | 0 | 0.0 | LUAD | 6.9 | 1.5 (1.0 – 2.1) | 10 | 4KKJA | 1 | 0 | 0 | 1 | |
|
| |||||||||||||
| PARP15 | Poly [ADP-ribose] polymerase 15 | 0 | 0.0 | KIRC | 3.1 | 1.5 (1.1 – 2.1) | 5 | 3GEYA | 1† | 1 | 0 | 0 | |
†
Has a binding site that has a co-crystallized small molecule inhibitor.