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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Trends Pharmacol Sci. 2016 Aug 5;37(10):811–821. doi: 10.1016/j.tips.2016.07.002

Fig. 2. Model of proposed TTP mechanism of action.

Fig. 2

The diagram shows a schematic representation of the “closed-loop” model [47] of a typical mRNA being translated in the absence of TTP (left), as in serum deprived fibroblasts or macrophages, and after the induction of TTP (right), as in serum-stimulated fibroblasts or LPS-stimulated macrophages. TTP binds to the AREs of its target mRNAs, often on multiple sites, and interacts with both polyA binding protein (PABP) as a possible means of localizing near the polyA tail, and NOT1, which can bring its associated deadenylases CAF1 and CCR4 into proximity with the 3’ end of the polyA tail. The net result of the TTP binding is destabilization and decreased translation of the mRNA. See the text for further details.