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. 2016 Sep 21;7:166. doi: 10.3389/fgene.2016.00166

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Copyright © 2016 Löwe, Kremling and Marin-Sanguino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Accumulated error for perturbations of different sizes in the reduced TCA model. Each point represents one simulation where the fast variables were perturbed by |dy| and the overall error E was calculated.