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. 2016 Sep 21;7:356. doi: 10.3389/fimmu.2016.00356

Figure 1.

Figure 1

Antiviral activity of NK cells. Percentage HIV replication inhibition after 7 days of culture, normalized to untreated NK cells. CD4+ T cells were isolated, stimulated, and infected with JR-CSF. Infected targets were cultured with autologous NK cells in triplicate at a ratio 1:1. Each color represents cells from a different donor. At physiologically relevant doses, VOR and RMD did not have significant impact in the antiviral activity of the NK cells, while exposure to PNB and ING impaired NK cell viral inhibition capacity. On the contrary, NK treatment with PROST improves antiviral activity of NK cells. p-values were calculated using a Wilcoxon matched-pairs signed rank test. N = 12. VOR, vorinostat; RMD, romidepsin; PNB, panobinostat; PROST, prostratin; ING, ingenol.