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. 2016 Sep 21;7:323. doi: 10.3389/fphar.2016.00323

FIGURE 2.

FIGURE 2

Apolipoprotein A-I (apoA-I) has multiple protective functions in the normal and diseased lung. Apolipoprotein A-I has multiple protective and beneficial functions in the normal lung (Wang et al., 2010) and in a variety of pulmonary disorders, including acute lung injury (ALI) (Yan et al., 2006; Jiao and Wu, 2008; Li et al., 2008; Van Linthout et al., 2011; Kwon et al., 2012; Madenspacher et al., 2012; Sharifov et al., 2013), asthma (Nandedkar et al., 2011; Dai et al., 2012; Yao et al., 2011; Park et al., 2013), cigarette smoke-induced emphysema (Kim et al., 2016), influenza pneumonia (Van Lenten et al., 2002, 2004), lung cancer (Zamanian-Daryoush et al., 2013), pulmonary hypertension (Sharma et al., 2014) and idiopathic pulmonary fibrosis (IPF) (Kim et al., 2010; Lee et al., 2013). Data addressing the role of apoA-I in lung disease have primarily been generated in experimental animal models, although several studies have suggested that apoA-I may be associated with decreased disease severity in subjects with asthma (Barochia et al., 2015, 2016) and IPF (Kim et al., 2010), which are indicated.