Table 6.

Mean and SD and the main and interaction effects given by the ANCOVA for repeated measurements controlling for AGE for the group with and without fatigue according to the FSS.

	Fatigue (n = 17)		No fatigue (n = 25)		Healthy controls (n = 13)		Sign.
	T1	T2	T1	T2	T1	T2
	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)
BDI	7.29 (7.32)	6.41 (7.75)	4.84 (4.64)	2.8 (2.48)	3.23 (4.44)	1.92 (2.22)
EDSS	4.56 (1.27)	3.91 (1.28)	3.04 (1.95)	3.39 (1.83)	N/A	N/A	a, b
MSFC	−0.18 (0.44)	−0.07 (0.34)	−0.06 (0.57)	0.07 (0.62)	0.47 (0.41)	0.57 (0.34)
PASAT	42.50 (12.60)	47.13 (8.52)	45.20 (11.10)	47.28 (10.70)	47.77 (10.32)	51.54 (11.23)
Lesion load	3.71 (2.57)	3.80 (2.61)	7.07 (15.77)	7.09 (15.99)	0.03 (0.08)	0.07 (0.18)
TBV	1201.01 (109.05)	1178.80 (103.78)	1219.12 (130.77)	1209.59 (128.02)	1280.9 (72.55)	1275.3 (75.80)
BPF	0.81 (0.04)	0.80 (0.04)	0.81 (0.04)	0.81 (0.04)	0.85 (0.15)	0.84 (0.02)
Lateral ventricles	40.92 (24.68)	41.92 (25.03)	36.00 (30.87)	36.65 (31.25)	16.78 (6.43)	16.88 (6.80)
Volume of third and fourth ventricle	4.22 (1.47)	4.31 (1.44)	3.43 (1.46)	3.61 (1.43)	2.72 (1.27)	2.85 (1.31)
CCI	0.326 (0.067)	0.352 (0.067)	0.329 (0.068)	0.368 (0.071)	0.43 (0.05)	0.45 (0.04)	b
Axial and radial diffusivity of the corpus callosum	0.0013 (0.0001)	0.0013 (0.0001)	0.0013 (0.0001)	0.0013 (0.0002)	0.0012 (0.0000)	0.0012 (0.0001)

BDI, Beck’s Depression Inventory; BPF, brain parenchymal fraction; CCI, corpus callosum index; EDSS, Expanded Disability Status Scale; FSS, Fatigue Severity Scale; FSMC, Multiple Sclerosis Functional Composite; MS, multiple sclerosis; PASAT, Paced Auditory Serial Addition Test; TBV, total brain volume.

Significant difference (p < 0.05) for a: main factor GROUP, b: significant main factor TIME, and c: significant interaction group × time.