Figure 3.

Histological study of bone regeneration in bone defects optionally containing CHA granules. (A) control group at 2 weeks after implantation—the bone defect is filled with connective tissue; (B) CHA group at 2 weeks after implantation—the granules are surrounded with connective tissue, in some granules osteoid formation can be discerned ; (C) CHA group at 2 weeks after implantation—near bone edges granules are surrounded with woven bone; (D) control group at 4 weeks after implantation—the bone defect is filled with connective tissue and woven bone; (E) CHA group at 4 weeks after implantation—the granules in the center of the defect are mostly surrounded with trabecular and woven bone; (F) CHA group at 4 weeks after implantation (higher magnification)—woven bone is forming around and inside CHA granule; (G) control group at 8 weeks after implantation—newly formed bone can be discerned at the edges of the bone defect; (H) CHA group at 8 weeks after implantation—trabecular bone has formed between CHA granules; (I) CHA group at 8 weeks after implantation—near bone edges granules are integrated in well-formed trabecular bone.