Table 2.

Short-term changes in M1 glutamate and GABA efflux immediately after l-DOPA^a

Lesion status	Treatment	Glutamate	GABA
Sham	Acute l-DOPA	—	—
Ipsilateral to lesion	Acute l-DOPA	↓	↓ orb ↑
Contralateral to lesion	Acute l-DOPA	↓ orb ↑	—
Sham	Chronic l-DOPA	—	—
Ipsilateral to lesion	Chronic l-DOPA	—	↑
Contralateral to lesion	Chronic l-DOPA	↑	↑

^aChanges in amino acids (as percentage of baseline) observed over a 3 h period immediately after l-DOPA administration.

^bModulation appeared to depend upon the severity of dyskinesia displayed by the rat (see Figs. 5F, 7F).