Table 3.
M1 microinfusion | Dyskinesia | Intact limb motor performance | Lesioned limb motor performance |
---|---|---|---|
D1 antagonist | ↓ | — | ↓ |
NMDA antagonist | — | — | — |
AMPA antagonist | ↓ | — | — |
GABAA agonist | ↓ | ↓ | — |
GABAB agonist | — | ↓ | — |
aIn lesioned rats, M1 microinjection of various agonists and antagonists affected behavioral output caused by systemic l-DOPA. ↓, Decrease in dyskinesia severity or decrease in motor performance.