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Modulation of l-DOPA-induced behavioral effects by M1 microinjectionsa
| M1 microinfusion | Dyskinesia | Intact limb motor performance | Lesioned limb motor performance |
|---|---|---|---|
| D1 antagonist | ↓ | — | ↓ |
| NMDA antagonist | — | — | — |
| AMPA antagonist | ↓ | — | — |
| GABAA agonist | ↓ | ↓ | — |
| GABAB agonist | — | ↓ | — |
aIn lesioned rats, M1 microinjection of various agonists and antagonists affected behavioral output caused by systemic l-DOPA. ↓, Decrease in dyskinesia severity or decrease in motor performance.
