Table 3b. Multivariable Cox model on overall survival in 55 NPM1-mutated patients with acute myeloid leukemia (including patients in complete remission with measurement of minimal residual disease and patients with refractory disease).
| HR (95%-CI) | P-value | |
|---|---|---|
| FLT3-ITD | 0.58 (0.17–1.93) | 0.37 |
| Log10(LDH) (at diagnosis) | 6.65 (1.25–35.3) | 0.03 |
| Percentage of BM blasts at diagnosis; 10% increase | 1.24 (0.90–1.72) | 0.19 |
| Age at the time of allogeneic HSCT; 10 years increase | 1.56 (0.92–2.64) | 0.10 |
| Achievement of CR and pre-transplant MRD status (reference RD) | ||
| CR, MRD-positive | 0.70 (0.29–1.70) | 0.02 |
| CR, MRD-negative | 0.11 (0.02–0.50) | |
Abbreviations: BM, bone marrow; CI, confidence interval; CR, complete remission; HR, hazard ratio; HSCT, hematopoietic stem cell transplantation; ITD, internal tandem duplication; LDH, lactate dehydrogenase; MRD, minimal residual disease; RD, refractory disease.