. 2016 Jul 8;6(7):e442. doi: 10.1038/bcj.2016.51

Table 2. Univariate and multivariate analysis of leukemia-free survival (LFS) and overall survival (OS).

	LFS					OS
	P-value	Hazard ratio	95% CI		P-value	Hazard ratio	95% CI
			Lower	Upper			Lower	Upper
Univariate analysis
Male gender	0.977	0.99	0.59	1.67	0.448	1.27	0.68	2.38
Age ⩾40 years	0.807	1.07	0.63	1.80	0.013	2.31	1.20	4.48
WCC ⩾100 × 10⁹/l	0.557	1.54	0.37	6.42	0.010	5.04	1.46	17.37
BM blasts ⩾70%	0.762	0.91	0.48	1.72	0.010	2.43	1.23	4.79
>1 induction to CR1	0.584	0.82	0.40	1.68	0.299	1.50	0.70	3.21
HSCT at CR1	0.006	0.28	0.11	0.70	0.246	0.60	0.25	1.43
Mutations in signaling	0.020	3.42	1.22	9.63	0.047	4.26	1.02	17.80
Mutations in methylation	0.030	2.26	1.08	4.72	0.940	0.96	0.37	2.50
KIT-AL	0.004	2.46	1.33	4.55	0.001	3.09	1.56	6.12
TET2	0.019	2.64	1.17	5.97	0.996	1.00	0.35	2.85
RAS	0.785	0.91	0.45	1.84	0.804	0.90	0.41	2.00
FLT3	0.664	0.80	0.28	2.23	0.966	0.98	0.30	3.19
RAD21	0.284	0.57	0.20	1.60	0.406	0.61	0.18	1.98
KIT-AL^Neg and TET2^Neg	0.001	0.35	0.19	0.65	0.015	0.43	0.22	0.85

Multivariate analysis
Age ⩾40 years	–	–	–	–	0.013	2.36	1.19	4.65
WCC ⩾100 × 10⁹/l	–	–	–	–	0.109	2.90	0.79	10.65
BM blasts ⩾70%	–	–	–	–	0.036	2.16	1.05	4.44
KIT-AL	0.001	2.84	1.50	5.36	–	–	–	–
TET2	0.004	3.43	1.48	7.96	–	–	–	–

Abbreviations: AL, activation loop; BM, bone marrow; CI, confidence interval; CR1, first complete remission; HSCT, hematopoietic stem cell transplantation; WCC, white cell count.

KIT-AL^Neg and TET2^Neg was not entered into multivariate analysis, as it would mutually exclude KIT-AL and TET2. Parameters showing statistical significance are highlighted in bold.