Table 2. Definitions of evolving changes in monoclonal protein (eMP) and hemoglobin (eHb).

Criteria	Definition
Evolving monoclonal protein level (eMP)	⩾10% Increase in serum M-protein and/or involved immunoglobulin level within the first 6 months of diagnosis (only if baseline M-protein was ⩾3 g/dl) and/or ⩾25% increase in serum M-protein and/or involved immunoglobulin level within the first 12 months of diagnosis (for any level of M-protein) plus minimum increase of 0.5 g/dl in M-protein or 500 mg/dl in immunoglobulin or both
Evolving hemoglobin level (eHb)	⩾0.5 g/dl Decrease in hemoglobin within the first 12 months of diagnosis