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. 2016 Sep 21;6:33680. doi: 10.1038/srep33680

Figure 3. Effect of mIL-18BP on Ovx‐induced increases in CD4+CD28+ T cells and B cells.

Figure 3

(a,b) The CD4+CD28+ T‐cell population was decreased in the BM of Ovx mice and mIL-18BP treated group reversed this loss of CD28. No difference was observed in sham and sham group treated with mIL-18BPd (c) IL-18 transcript levels in CD4+ T cells isolated from Ovx and sham group mice. (d,e) The population of B220+ cells was increased in BM of Ovx mice and mIL-18BP significantly decreased the percentage of B220+ cells. (f) IL-18 transcript levels in B220+ cells isolated from Ovx and sham group mice. Statistical analysis was performed by ANOVA method followed by the Newman–Keuls test of significance using Prism version 3.0 software. n = 10 mice/group; data are presented as mean ± SE; ***p < 0.001 compared with Ovx; cp < 0.001 compared with Sham group; rp < 0.001 compared with Sham + mIL-18BPd. Data represent three independent experiments and expressed as mean ± SE with 95% confidence interval. Two tailed student’s t- test was used to compare between two means using Prism version 3.0 software.*P < 0.05 compared with sham-CD4+ group.**P < 0.01 compared with sham- B220+ group.