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. 2016 Sep 21;6:33680. doi: 10.1038/srep33680

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Copyright © 2016, The Author(s)

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(a) Ovx induces the proliferation of Th17 cells while administration of mIL-18BP reduces the number of Th-17 cells. (b) Quantification of the FACS data. Percentage of Th17 cells was higher in Ovx animals and treatment with mIL-18BPd inhibited this increase. (c,d) Percentage of CD4+CD25+ cells and (e,f) CD25+FOXP3+ cells was measured by FACS. Percentage of CD4+CD25+ cells and CD25+FoxP3+ cells were significantly lower in Ovx group animals. Treatment of Ovx mice with mIL-18BP led to significant increase in CD4+CD25+ and CD25+FoxP3+ Treg cells. n = 10 mice/group; data are presented as mean ± SE; ***p < 0.001 compared with Ovx group; **p < 0.01 compared with Ovx group; ^ap < 0.05 compared with Ovx+mIL-18BPd group.