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. 2016 Sep 21;6:32927. doi: 10.1038/srep32927

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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C57BL/6 mice and IL-22^−/− mice were infected i.p. with 500 T. cruzi trypomastigotes. Tissue sections of spleen (A,E), liver (B,F), heart (C,G) and colon (D,H) were stained with H&E (A–D) or with azan trichrome (E–H). Representative sections from five mice per group (2 uninfected mice per group) are shown. Magnification: spleen, liver, colon 100x; heart 200x. Liver derived enzymes ALT and AST (I) and CK (J) were quantified in sera at the indicated time points after infection. Results are expressed as means ± standard deviations of 5 mice per group (2–5 uninfected mice per group). Similar results were obtained in two independent experiments.