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. 2016 Jul 20;80(4):554–565. doi: 10.1038/pr.2016.105

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Copyright © 2016 Official journal of the International Pediatric Research Foundation, Inc.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effects of Keto and/or Caff on retinal and choroidal HIF_1α and 8-isoPGF_2α. The upper panel (a–d) are data at P14 (IH), and the lower panel (e–h) are data at P21 (IHR). The white bars represent the room air (RA) controls and the black bars represent the intermittent hypoxia (IH) at P14 or recovery from IH (IHR) at P21. Retinal HIF_1α are panels a and e; choroidal HIF_1α are panels c and g; retinal 8-isoPGF_2α are panels b and f; and choroidal 8-isoPGF_2α are panels d and h at P14 (upper panel) and P21 (lower panel). Groups are as described in Figure 1. Data are presented as mean ± SEM (n = 6 samples/group). *P < 0.01; **P < 0.01 vs. Sal/Sal RA; ^‡P < 0.01 vs. Sal/Sal IH; ^§P < 0.01 vs. RA.