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. 2016 Jul 20;80(4):554–565. doi: 10.1038/pr.2016.105

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Copyright © 2016 Official journal of the International Pediatric Research Foundation, Inc.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Retinal flatmounts of P21 RA controls, Sal/Sal IHR, and Keto/Caff-treated IHR retinas. Panels a and b represent RA controls, panels c and d represent Sal/Sal IHR groups, and panels e and f represent Caff/Keto-treated IHR groups. RA images show normal retinal vasculature in the optic disk (panel a) and periphery (panel b). The placebo-treated IHR groups show punctate hemorrhages at the optic disk (panel c, arrow), and neonvascularization, vascular tufts, and tortuous, dilated vessels consistent with severe OIR at the periphery (panel d, arrows). Caff/Keto reduced the severity of OIR with evidence of capillary dropout at the optic disk (panel e, arrow) and periphery (panel f, arrows). Images are 4× magnification, bar scale is 200 µm.