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| Compound | Kinase | % Ctrl |
Kd (μM) | |
|---|---|---|---|---|
| 0.1 μM | 10 μM | |||
| Sunitinib | TNIK | 37 | 0 | 0.025 |
| Dasatinib | TNIK | 82 | 11 | 2.0 |
| Gefitinib | TNIK | 100 | 34 | 6.9 |
| Lapatinib | TNIK | 90 | 93 | >10 |
| Flavopiridol | TNIK | 92 | 33 | >10 |
| Mebendazole | TNIK | 97 | 8.2 | ND |
| ABL2 | 100 | 33 | ND | |
| MEK1 | 100 | 38 | ND | |
| EGFR | 100 | 83 | ND | |
| ACK1 | 100 | 98 | ND | |
| PDPK1 | 100 | 100 | ND | |
| PIK3CA | 100 | 100 | ND | |
The values were reported as percentage of control, where lower value indicates stronger binding. ND – not determined.
