Table 2. Sensitivities, specificities, positive predictive values and negative predict values of the biomarkers for asymptomatic neurosyphilis diagnosis.
| Biomarker | AUC(95% CI) | Sensitivity(95% CI) | Specificity(95% CI) | PPV* (95% CI) | NPV#(95% CI) |
|---|---|---|---|---|---|
| CSF CXCL13 | 0.922 (0.880–0.965) | 81.9 (71.6–89.2) | 88.2 (80.5–93.4) | 84.0 (73.8–90.8) | 86.7 (78.7–92.1) |
| CSF CXCL8 | 0.866 (0.808–0.923) | 71.1 (60.0–80.3) | 89.1 (81.4–94.0) | 83.1 (71.9–90.6) | 80.3 (71.9–86.7) |
| CSF CXCL10 | 0.886 (0.834–0.938) | 69.5 (58.2–78.9) | 90.1 (82.6–94.7) | 83.8 (72.4–91.3) | 80.0 (71.7–86.4) |
| CSF/Serum CXCL13 | 0.941 (0.901–0.981) | 82.9 (71.6–90.5) | 99.0 (94.0–100) | 98.3 (89.7–100) | 89.6 (82.1–94.3) |
| CSF/Serum CXCL8 | 0.803 (0.730–0.875) | 68.5 (56.4–78.6) | 72.1 (62.3–80.2) | 63.3 (51.6–73.6) | 76.5 (66.7–84.3) |
| CSF/Serum CXCL10 | 0.892 (0.836–0.947) | 77.0 (65.5–85.7) | 92.7 (85.6–96.5) | 87.7 (76.6–94.2) | 85.6 (77.7–91.1) |
| Model1 | 0.925 (0.885–0.964) | 77.9 (63.8–83.3) | 92.6 (86.0–96.3) | 87.3 (76.8–93.7) | 84.2 (76.6–89.7) |
| Model2 | 0.938 (0.896–0.981) | 86.8 (75.9–93.4) | 94.6 (88.2–97.8) | 90.8 (80.3–96.2) | 92.2 (85.3–96.1) |
| CSF VDRL | 0.890 (0.829–0.950) | 77.9 (71.6–89.2) | 100 (96.2–100) | 100 (93.3–100) | 89.1 (82.3–93.5) |
*PPV, positive predictive value; #NPV, negative predictive value; CI, confidence interval.