Table 2.
Genome wide significant regions of excess African ancestry (negative Z-score) and reduced (positive Z-score) associated with breast cancer at |Z| > 4 in case-only analyses and corresponding case-control resultsa.
| Locus | All breast cancers |
ER+ breast cancers |
ER- breast cancers |
TNBC |
Breast cancer GWAS SNPs | ||||
|---|---|---|---|---|---|---|---|---|---|
| Zc/Zcc | ORb (95% CI) | Zc/Zcc | ORb (95% CI) | Zc/Zcc | ORb (95% CI) | Zc/Zcc | ORb (95% CI) | ||
| 4p16.3 | -2.4/-0.9 | 1.05 (0.93–1.18) | -4.1/-2.7 | 1.22 (1.06–1.41) | 0.7/1.6 | 0.86 (0.72–1.02) | 0.7/1.2 | 0.86 (0.68–1.09) | – |
| 10q26 | -4.7/-2.1 | 1.12 (1.00–1.26) | -3.3/-1.2 | 1.08 (0.94–1.24) | -3.5/-1.7 | 1.16 (0.97–1.38) | -1.5/-0.06 | 0.99 (0.79–1.26) | rs11199914 rs3750817 rs35012336 rs10736303 rs2981579 rs2981578 rs2981575 rs1219648 rs1219642 rs2912774 rs2936870 rs2420946 rs2981582 rs2935717 |
| 11q13.2 | 3.9/1.9 | 0.91 (0.82–1.00) | 4.8/3.1 | 0.83 (0.75–0.93) | 0.5/-0.6 | 1.04 (0.90–1.21) | -1.1/-1.5 | 1.16 (0.95–1.42) | rs614367 rs3903072 rs537626 |
| 17q25.1 | -3.8/-1.7 | 1.09 (0.98–1.22) | -4.3/-2.6 | 1.20 (1.05–1.37) | -0.2/0.7 | 0.93 (0.79–1.11) | -0.6/-0.1 | 1.00 (0.80–1.26) | – |
a|Z|≥ 4.0 case-only analysis results are presented only for regions with case-control results |Z|≥ 2.0, P < 0.05. bOdds ratio and 95% confidence interval per African allele estimated from the admixture mapping case-control analysis. Odd ratios were adjusted for individual African ancestry, study site, age, geographic region, and DNA source. TNBC, triple negative breast cancer. Zc, Z-score from the case-only analysis. Zcc, Z-score from the case-control analysis.