Table 3.

Most significant single independent SNP associations in the African American Breast Cancer (AABC) consortium within genomic regions identified in admixture mapping of AMBER.

Locus/Breast Cancer subtype	Local African ancestry	Position (bp)	Allelesa	OR (95% CI)	P-value	Effect allele frequency
						AABC	AFRb	EURc
4p16, ER+	Excess
rs112545418		2279036	A/G	1.46 (1.24–1.72)	4.0 × 10-6	0.13	0.14	0.01
10q26, all breast cancer	Excess
rs12244041		133275151	T/A	1.34 (1.21–1.46)	3.9 × 10-6	0.78	0.83	0.68
11q13, ER+	Deficit
rs77274510		61995513	A/G	3.13 (2.60–3.58)	5.8 × 10-6	0.012	< 0.01	0.059
rs117564384		62011320	A/G	2.97 (2.50–3.44)	6.8 × 10-6	0.012	< 0.01	0.051
rs116638271		67441627	G/A	2.31 (1.95–2.67)	4.7 × 10-6	0.97	0.97	1.0
17q25, ER+	Excess
rs55850050		74453990	T/C	1.55 (1.23–1.94)	1.6 × 10-4	0.062	0.027	0.16

^aEffect allele/reference ^bAfrican ancestry populations from 1000 Genomes Project ^cEuropean ancestry populations from 1000 Genomes Project