Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 19;213(10):1973–1981. doi: 10.1084/jem.20151065

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Drennan et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 4. — MALT1 deficiency rescues iNKT cell development in CD4-cre;A20^F/F mice. (A) Frequency and absolute iNKT cell counts (B) in thymus and liver of MALT1^+/− (n = 13), MALT1^−/− (n = 12), CD4-cre;A20^F/F;MALT1^+/− (n = 6), and CD4-cre;A20^F/F;MALT1^−/− (n = 7) mice, respectively. Data are pooled from four independent experiments. (C) Serum IL-4 concentration in MALT1^+/− (n = 26) and MALT^−/− (n = 20) mice after i.p. injection of α-GalCer. Results are pooled from two independent experiments. (D and E) Frequency of MALT1^+/− (n = 4) and MALT1^−/− (n = 4) iNKT cells recovered from CD45.1 congenic mice after transfer of CFSE-labeled CD8-depleted thymocytes. (F) Homeostatic proliferation of MALT1^+/− and MALT1^−/− iNKT cells in the livers of congenic mice 8 d after transfer. Data are from two independent experiments pooled. (G–I) Frequency and absolute iNKT cell counts in thymus, spleen, and liver of control A20^F/F;MALT1^F/F (n = 6) and CD4-cre;A20^F/F;MALT1^F/F (n = 6) mice, respectively. FACS dot blots in H are gated on βTCR⁺CD1d-αGC⁺ iNKT cells from each organ. Data are pooled from three independent experiments.*, P < 0.05; **, P < 0.01. n.s., not significant.