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. 2016 Sep 19;213(10):1999–2018. doi: 10.1084/jem.20160393

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© 2016 Bajrami et al.

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Figure 3. — G-CSF specifically inhibits MIP-2–induced neutrophil mobilization from the BM. (A) MIP-2–induced neutrophil mobilization from the BM in the presence or absence of G-CSF. C57BL/6 mice were i.v. injected with the indicated cytokines. (B) Total numbers of neutrophils remaining in the BM 60 min after each treatment. AMD3100 is a small molecule antagonist of CXCR4. (C) MIP-2 induces eosinophil mobilization. (D) MIP-2 does not have a significant effect on monocyte mobilization from the BM. (E) CXCR4 antagonist AMD3100 further enhances MIP-2–induced neutrophil mobilization. Mice were i.v. injected with 1 µg MIP-2, 2.5 µg G-CSF, or 0.05 mg AMD3100 as indicated. All data shown are means ± SD of three experiments (n = 10 mice for each group). *, P < 0.01 by Student’s t test versus control (mice treated with PBS at each time point).