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. 2016 Sep 19;213(10):1999–2018. doi: 10.1084/jem.20160393

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© 2016 Bajrami et al.

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Figure 7. — Blocking G-CSF increases rapid neutrophil mobilization during early-stage acute inflammation. (A) The G-CSF concentration in blood serum after administration of E. coli. 10⁶ CFU E. coli or PBS (as control) was i.p. injected. (B) Mice were treated with 100 µg G-CSF antibody for 1 h before administration of E. coli. IgG was administered to the control group. (C) PB neutrophil counts were measured using a HemaVet 850 hematology system. Fold increases compared with mice treated with E. coli only (or PBS only as a control) at each time point are shown. (D) Total number of neutrophils in the BM. (E) The number of neutrophils in peritoneal lavage was measured by flow cytometry analysis 2 and 6 h after E. coli administration. (F) Blocking G-CSF activity does not alter KC and MIP-2 levels in mice i.p. injected with E. coli. n = 4–6 mice. Data shown are means ± SD of three experiments. *, P < 0.01 versus mice treated with IgG.