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. 2016 Sep 19;213(10):2129–2146. doi: 10.1084/jem.20160526

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© 2016 Tai et al.

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Figure 8. — Increased abundance of Fusobacteria is associated with diabetes development. (A) Abundance of Fusobacteria and L. goodfellowii in WT NY8.3NOD and MyD88^−/−NY8.3NOD mice. Two-tailed Mann-Whitney test (fecal samples) or two-tailed unpaired Student’s t test with Welch’s correction (oral samples) was used. n = 7–16 mice/group from two independent experiments. Data are mean ± SEM. (B) Abundance of Fusobacteria in fecal samples from the control, cohoused, and OT MyD88^−/−NY8.3NOD mice. Repeated measures ANOVA with Tukey’s posthoc test was used for analysis. (C) Abundance of Fusobacteria in diabetic and nondiabetic female NOD mice. Student’s t test was used. (D) Bacterial DNA was extracted from fecal samples of female NOD mice every two weeks from 6 wk old until diabetes onset. Results from three time points are shown. Repeated measures ANOVA with Tukey’s posthoc test was used. (B–D) Data were pooled from at least two independent experiments. *, P < 0.05; ***, P < 0.001.