Table 1.
Main prostaglandin and leukotriene polymorphisms associated with different human inflammatory conditions.
| Gene | Polymorphism | Condition | Population | References |
|---|---|---|---|---|
| Prostaglandin I2 receptor (PTGIR) | A984C | Cerebral infarction | Japanese | Shimizu et al., 2013 |
| V53V, S328S | Deep vein thrombosis | Italian | Patrignani et al., 2008 | |
| 1915T>C | NERD | Korean | Thompson et al., 2007 | |
| Prostaglandin D2 receptor (PTGDR) | −441C>T, −549T>C, and −197T>C haplotypes | Asthma | American | Oguma et al., 2004 |
| −613C>T | Allergy to pollen and mites | Spanish | Isidoro-García et al., 2011 | |
| −197T>C | Allergic asthma | Spanish | Isidoro-García et al., 2011 | |
| −613C>T, −549T>C, −441C>T, and −197T>C diplotype | Nasal polyposis with and without asthma, and aspirin triad | Spanish | Benito Pescador et al., 2012 | |
| −731A>G, 6651C>T | Asthma, atopic asthma, and bronchial hyperreactivity | British and Danish | Zhu et al., 2007 | |
| rs8004654 | NIUA | Spanish | Cornejo-Garcia et al., 2012 | |
| Prostaglandin D2 receptor 2 (CRTH2) | 1544G>C, 1651A>G | Asthma and IL13 levels | Chinese | Wang et al., 2009 |
| 1538A>G | Food allergy sensitization | German | Cameron et al., 2009 | |
| −466T>C | NERD | Korean, and Japanese | Palikhe et al., 2010; Kohyama et al., 2012 | |
| −466T>C | Antihistamine requirements in chronic urticaria | Korean | Palikhe et al., 2009 | |
| Prostaglandin E receptor 1 (PTGER1) | 1544G>C, 1651A>G | Asthma | African American, Chinese | Huang et al., 2004 |
| rs3810253, rs3810255 | NERD | Spanish | Ayuso et al., 2015 | |
| Prostaglandin E receptor 2 (PTGER2) | rs17197 | Essential hypertension | Japanese | Sato et al., 2007 |
| −616C>G, −166G>A | NERD | Korean | Kim et al., 2007b | |
| rs1254598 | NERD | Spanish | Ayuso et al., 2015 | |
| Prostaglandin E receptor 3 (PTGER3) | rs977214 | Protective effect in preterm birth | Norwegian | Ryckman et al., 2010 |
| 1388T>C | Increased asthma risk | Korean | Park et al., 2007 | |
| Prostaglandin E receptor 4 (PTGER4) | rs7720838 | Crohn disease | American and German, German | Glas et al., 2012; Prager et al., 2014 |
| rs4434423 | Primary graft dysfunction | Multicentered cohort including different ethnicities | Diamond et al., 2014 | |
| rs10440635 | Ankylosing spondylitis | Han Chinese | Chai et al., 2013 | |
| −1254G>A | NERD | Korean | Kim et al., 2007b | |
| rs13186505, rs4133101 | NIUA | Spanish | Cornejo-Garcia et al., 2012 | |
| rs4495224 | NERD | Spanish | Ayuso et al., 2015 | |
| −1254G>A | NECD | Korean | Palikhe et al., 2012 | |
| Thromboxane A2 receptor (TBXA2R) | rs768963 | Cerebral infarction | Han Chinese | Shao et al., 2015 |
| rs768963 | Cerebral infarction, large artery atherosclerosis, and small artery occlusion subtype. | Chinese | Zhao et al., 2013 | |
| 795T>C | NERD | Korean, Japanese | Kim et al., 2007b; Kohyama et al., 2012 | |
| Cysteinyl leukotriene receptor 1 (CYSLTR1) | G300S | Atopy and asthma | Tristan da Cunha | Thompson et al., 2007 |
| 634C>T | NECD | Korean | Kim et al., 2007a | |
| rs320995 | Asthma | Spanish | Arriba-Mendez et al., 2006 | |
| 927T>C | Atopy severity | British | Hao et al., 2006 | |
| rs320995 | NIUA | Spanish | Cornejo-Garcia et al., 2012 | |
| −634C>T, −475A>C, −336A>G | NERD | Korean | Kim et al., 2006 | |
| −634C>T | NERD | Korean | Kim et al., 2007c | |
| Cysteinyl leukotriene receptor 2 (CYSLTR2) | M201V | Atopy | Tristan da Cunha | Thompson et al., 2003 |
| 601A>G | Asthma | Danish and American | Pillai et al., 2004 | |
| −1220A>C | Asthma | Japanese | Fukai et al., 2004 | |
| rs320995 | NERD | Spanish | Ayuso et al., 2015 | |
| −819T>G, 2078C>T, 2534A>G | NERD | Korean | Park et al., 2005 |
NECD, non-steroidal anti-inflammatory drugs-exacerbated cutaneous disease; NERD, non-steroidal anti-inflammatory drugs-exacerbated respiratory disease; NIUA; non-steroidal anti-inflammatory drugs-induced urticaria/angioedema.