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. Author manuscript; available in PMC: 2016 Sep 21.
Published in final edited form as: Cell Rep. 2016 Aug 25;16(10):2618–2629. doi: 10.1016/j.celrep.2016.08.014

Figure 6. Radiation resistance in Mdm2S394A mice is governed by hematopoietic stem and progenitor cells (HSPCs).

Figure 6

(A) Quantification of lineage-defined hematopoietic cells in bone marrow of WT and Mdm2S394A mice in the absence of treatment (top) and 24 hours after exposure to 5 Gy IR (bottom) (n = 3-4, ±SEM).

(B) Quantification of L−S−K (CMP) and L−SK (HSPC) hematopoietic progenitor cells in bone marrow of WT and Mdm2S394A mice described in (A).

(C) Schematic showing the experimental design of bone marrow repopulation assays. PB, peripheral blood; BM, bone marrow.

(D) Leukocyte marker analysis of peripheral blood of recipient mice described in (C) at 4 (n = 15), 8 (n = 15) and 10 (n = 5) weeks after bone marrow transplantation (±SEM).

(E) Leukocyte marker analysis of total bone marrow of recipient mice described in (C), untreated, 1 and 12 days after exposure to 5 Gy IR (n = 5, ±SEM). *P < 0.05, **P < 0.01 (Student’s t-tests).