Fig. 2.
Functional Abilities Questionnaire (FAQ) predicted values adjusted for age and gender and stratified by levels of cerebrospinal fluid biomarkers and brain volume are shown plotted over years from baseline biomarker assessment. Higher scores indicate worse outcomes. Participants with abnormal biomarker levels and low brain volumes had the worst outcomes, compared to all other participants (all p’s < 0.05). Plots were similar for other non-cognitive outcomes including the Geriatric Depression Scale (GDS) and the Neuropsychiatric Inventory Questionnaire (NPI-Q).