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. Author manuscript; available in PMC: 2016 Sep 21.
Published in final edited form as: Neuron. 2015 Mar 4;85(5):911–925. doi: 10.1016/j.neuron.2015.01.019

Figure 3.

Figure 3

Homeoproteins bind to a wide range of molecules. The homeodomain contains a conserved 3-helix bundle flanked by variable N- and C-terminal domains that together form the homeoprotein. These domains make a plethora of interactions with DNA, RNA, GAGs and proteins. Consequently, homeoproteins are shown to regulate transcription, RNA processing and translation, DNA replication and damage response and are also implicated in cell signaling. Within the 2nd and 3rd DNA-binding α-helices are the motifs that permit the non-conventional secretion and internalization of the homeodomain.