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. Author manuscript; available in PMC: 2016 Sep 21.
Published in final edited form as: Neuron. 2015 Mar 4;85(5):911–925. doi: 10.1016/j.neuron.2015.01.019

Figure 4.

Figure 4

The graded expression of a morphogen creates several domains within the morphogenetic field, according to the Wolpert’s French flag paradigm (Wolpert, 1969). Each domain is characterized by the expression of a homeoprotein transcription factor (Blue-Yellow-Red) but the boundaries are initially fuzzy. In this model the further regularity and positioning of the boundary is permitted by the local diffusion of homeoproteins with self-activating and reciprocal inhibitory properties, thus acting as local Turing’s morphogens.