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Synergy exists between EphrinA5 and En1/2 in local growth cones. A. A consequence of EphrinA5/En1/2 synergistic activity is that En1/2 signaling does not operate in absence of EphrinA5 (knock out) or in excess of EphrinA5 (gain of function) but only at EphrinA5 physiological concentrations. B. ATP signaling is driven by En1/2 through local translation and synergizes with EphrinA5 signaling to elicit growth cone responses (Stettler et al., 2012).
