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. 2016 Jul 20;38(9):830–838. doi: 10.1002/bies.201600100

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© 2016 The Authors BioEssays Published by WILEY Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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CCCH‐ZF‐RBP pathways destabilizing mRNA containing linear sequence motifs (TTP) or stem‐loop elements (Regnase and Roquin). A: Tristetraprolin (TTP)‐triggered degradation of mRNAs containing AU‐rich elements (AREs). A key step in this mechanism is recruitment of the Ccr4‐Caf‐Not mRNA deadenylation complex through interaction between TTP C‐terminal domain and Not1. B: Regnase‐mediated decay of mRNAs containing characteristic stem‐loop structures. This mechanism depends on Upf1 and the PIN‐domain endonuclease activity of the Regnase protein. C: Roquin targets secondary structure elements similar to those recognized by Regnase but destabilizes mRNA by recruiting the Ccr4‐Caf‐Not deadenylase.