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. 2016 Sep 17;94(11):1203–1219. doi: 10.1002/jnr.23762

Figure 1.

Figure 1

Processing and trafficking of GALC to the lysosome. GALC is produced in the ER and glycosylated (Glyc‐GALC) in the Golgi apparatus (GA). Glycans modified with M6P groups are recognized by M6PR. The M6PR‐GALC complex is transported to the early endosomal (EE) compartment, and, in the low‐pH environment of the late endosome (LE), the complex dissociates. The M6PR is recycled back to the GA, and GALC is delivered to the lysosome. GALC can also be trafficked via the constitutive secretory pathway and delivered to the lysosome via reuptake by the M6PR.