Table 5.
Recurrence (%) | Detection advance (months) | ||||
---|---|---|---|---|---|
Reference | Recruitment | Methods tested* | Intensive | Control | |
CEASL30 | 1982–1993 | CEA | –† | –† | 11 |
Ohlsson et al.17 | 1983–1986 | CEA, CT, endoscopy | 4 | ||
Kjeldsen et al.20 | 1983–1984 | Endoscopy | 26 | 26 | 9 |
Mäkelä et al.16 | 1988–1990 | CT | 42 | 39 | 5 |
Wang et al.27 | 1995–2001 | Endoscopy | 8 | 11 | 13 |
GILDA4 | 1998–2006 | CT, endoscopy, liver ultrasonography | 15 | 13 | 6 |
Wattchow et al.24 | 1998–2001 | Setting: surgeon- or GP-led | 2 | ||
FACS3 | |||||
CEA | 2003–2009 | CEA | 22 | 14 | 24 |
CT | 2004–2009 | CT | 20 | 14 | 30 |
CEA and CT | 2005–2009 | CEA, CT | 17·5 | 14 | 24 |
Only tests that were not the same in the two groups.
Only a minority of patients meeting the stringent carcinoembryonic antigen (CEA) criteria were randomized, so detection was similar in both randomized groups and effectively 100 per cent.