Figure 4.

Joint contact maps resulting from combining contact predictions from PconsC2 alone (lower diagonal) or PconsC2 and bbcontacts (upper diagonal) for the B. subtilis ComEC DUF4131 sequence from residues 10–167. Red dots on the diagonal mark residues predicted to be α‐helical, while β‐strand residues are marked in mid‐blue. Off diagonal blue points represent predicted contacts between residues determined by evolutionary covariance analysis. In the upper panel, those in darker blue are those found in both the PconsC2 and bbcontacts lists. Predicted contacts suggesting an antiparallel pairing between β‐strands from residues 135–140 and residues 161–166 are boxed. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]