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The proposed model of “circulating lipidome” in human NAFL and NASH. The development of NAFL is accompanied by increased de novo lipogenesis (DNL), Δ6 desaturase, and lipoxygenase (LOX) activity. With progression to NASH, the lipogenic activity levels off or declines modestly while the LOX activity increases. Simultaneously, there is a decrease in peroxisomal function and increase in levels of products of nonenzymatic oxidation of arachidonic (20:4n6) acid.
