Table 2.
Total Plasma Lipid Composition (nmol/g Plasma) in the Study Population
| Lipids | Control (n = 50) | NAFL (n = 25) | NASH (n = 50) |
|---|---|---|---|
| Total fatty acids | 1396.2 ± 41.3 | 1784.3 ± 139.7** | 1520.1 ± 42.6 |
| Saturated fatty acid (SFA) | 479.2 ± 14.1 | 631.4 ± 52.3** | 536.3 ± 17.5 |
| Myristic acid (14:0) | 26 ± 1.2 | 36.6 ± 3.5* | 31 ± 1.7 |
| Pentadecanoic acid (15:0) | 5.1 ± 0.3 | 5.6 ± 0.5 | 5.5 ± 0.3 |
| Palmitic acid (16:0) | 326.8 ± 10.4 | 449.3 ± 40.5*** | 366.1 ± 12.3 |
| Stearic acid (18:0) | 113.9 ± 3.5 | 132.9 ± 9.2 | 126.6 ± 4.1 |
| Arachidic acid (20:0) | 2.3 ± 0.1 | 2.3 ± 0.1 | 2.3 ± 0.1 |
| Behenic acid (22:0) | 3.7 ± 0.2 | 3.6 ± 0.2 | 3.6 ± 0.1 |
| Lignoceric acid (24:0) | 2.8 ± 0.1 | 2.7 ± 0.2 | 2.7 ± 0.1 |
| Monounsaurated fatty acid (MUFA) | 294.8 ± 11 | 461.4 ± 44.9*** | 366.3 ± 12*** |
| Total n7 fattty acids | 42.5 ± 2.2 | 72.3 ± 7.3*** | 58.4 ± 2.7*** |
| Total n9 fatty acids | 252.2 ± 9.2 | 388.4 ± 37.9*** | 307.6 ± 9.7*** |
| Myristoleic acid (14:1n5) | 1.7 ± 0.1 | 2.7 ± 0.3** | 2.2 ± 0.1* |
| Palmitoleic acid (16:1n7) | 25.4 ± 1.7 | 49.4 ± 4.9*** | 38.8 ± 2.2*** |
| Vaccenic acid (18:1n7) | 19.7 ± 0.8 | 26.4 ± 2.5** | 23.8 ± 1** |
| Oleic acid (18:1n9) | 243.2 ± 9 | 380.3 ± 37.5*** | 297.5 ± 9.4*** |
| Eicosenoic acid (20:1n9) | 3.5 ± 0.1 | 5.2 ± 0.5 | 4.8 ± 0.2 |
| Mead acid (20:3n9) | 1.7 ± 0.1 | 2.1 ± 0.2 | 2 ± 0.2 |
| Erucic acid (22:1n9) | 1.3 ± 0.1 | 1.3 ± 0.2 | 1.5 ± 0.3 |
| Nervonic acid (24:1n9) | 4.8 ± 0.2 | 4 ± 0.3 | 4.5 ± 0.2 |
| Polyunsaturated fatty acid (PUFA) | 612.1 ± 19.6 | 683 ± 45.7 | 609 ± 16.4 |
| Total n6 fatty acids | 556.1 ± 18.3 | 622 ± 42.9 | 557.8 ± 14.8 |
| Total n3 fatty acids | 54.6 ± 3.8 | 59.4 ± 4.1 | 49.9 ± 2.8 |
| Linoleic acid (18:2n6) | 420.3 ± 14.9 | 467.5 ± 36.6 | 412 ± 11.2 |
| γ-linolenic acid (18:3n6) | 7 ± 0.5 | 11.2 ± 1.1*** | 9.2 ± 0.4** |
| Eicosadienoic acid (20:2n6) | 4 ± 0.2 | 4.4 ± 0.4 | 4 ± 0.2 |
| Homo-γ-linolenic acid (20:3n6) | 19.2 ± 0.8 | 27.6 ± 2.3*** | 25.5 ± 1.4** |
| Arachidonic acid (20:4n6) | 101.7 ± 4.3 | 105.8 ± 5.4 | 102.7 ± 4.4 |
| Docosadienoic acid (22:2n6) | 0.3 ± 0 | 0.3 ± 0 | 0.3 ± 0 |
| Adrenic acid (22:4n6) | 4.1 ± 0.2 | 5.9 ± 0.7 | 5.1 ± 0.2 |
| Docosapentaenoic acid (22:5n6) | 3 ± 0.2 | 3.5 ± 0.3 | 3.4 ± 0.2 |
| α-linolenic acid (18:3n3) | 10.2 ± 0.7 | 13.7 ± 1.5 | 10 ± 0.5 |
| Stearidonic acid (18:4n3) | 0.8 ± 0.1 | 1.2 ± 0.1** | 0.9 ± 0.1 |
| Eicsoatetraenoic acid (20:4n3) | 1.3 ± 0.1 | 2 ± 0.2 | 1.6 ± 0.1 |
| Eicosapentaenoic acid (20:5n3) | 10.2 ± 1.9 | 10.8 ± 1.3 | 8.5 ± 0.9 |
| Docosapentaenoic acid (22:5n3) | 7.5 ± 0.4 | 9.9 ± 0.9** | 8.4 ± 0.4 |
| Docosahexaenoic acid (22:6n3) | 29.1 ± 1.9 | 25.6 ± 1.8 | 24.1 ± 1.6* |
| Total plasmalogens (dm) | 27.3 ± 1.6 | 23.7 ± 1.4 | 22.5 ± 1.1* |
| Dimethyl 16:0 (dm16:0) | 13.8 ± 0.6 | 11.6 ± 0.7 | 11.4 ± 0.5** |
| Dimethyl 18:0 (dm18:0) | 12 ± 0.8 | 12.3 ± 1 | 9.8 ± 0.6 |
| Dimethyl 18:1n7 (dm18:1n7) | 1.5 ± 0.1 | 1.1 ± 0.1 | 1.5 ± 0.2 |
| Dimethyl 18:1n9 (dm18:1n9) | 5.4 ± 0.4 | 4.3 ± 0.3 | 4.2 ± 0.2** |
▲
Data are shown in nmol/g, mean ± SEM.
*
P < 0.05.
**
P < 0.01.
***
P < 0.001 versus control.